Efektifitas Nephroprotektor Ekstrak Rumput laut merah (Eucheuma cottonii) Pada Mencit Yang Diinduksi Dengan Logam Berat Timbal

Giftania Wardani Sudjarwo, Nuraini Farida

Abstract


Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak rumput laut merah terhadap kadar SGOT dan SGPT serum tikus yang terpapar timbal per oral. Sampel yang digunakan adalah 50 tikus jantan yang dibagi menjadi 5 kelompok: kontrol negatif (tikus diberi sehari dengan CMC / karboksi metil selulosa 0,5%); kontrol positif (tikus diberikan setiap hari dengan CMC 0,5% dan memimpin 20 mg / kg BB secara oral satu kali dalam sehari selama 10 hari); dan kelompok perlakuan (tikus diberi ekstrak rumput laut merah 200 mg; 400 mg; 800 mg / kg BB secara oral sekali dalam sehari selama 28 hari dan timbal 20 mg / kg BB pada hari ke 7, satu jam setelah ekstrak rumput laut merah administrasi selama 21 hari Pada hari ke 14 diukur kadar MDA; SGOT dan SGPT Data MDA; SGOT dan SGPT dianalisis dengan ANOVA satu arah, dilanjutkan dengan uji LSD. Hasil penelitian menunjukkan bahwa, pemberian oral timbal asetat 20 mg / kg BB selama 21 hari menghasilkan peningkatan SGOT, SGPT dan MDA yang signifikan. Perlakuan dengan ekstrak rumput laut merah 800 mg / kg BB secara signifikan (P <0,05) menurunkan kadar SGPT, SGOT dan MDA yang meningkat dan dibandingkan dengan kontrol positif. Dari hasil penelitian ini disimpulkan bahwa ekstrak rumput laut merah memiliki aktivitas nephrotoprotective terhadap timbal asetat yang menginduksi hepatotoksisitas pada tikus.


Keywords


Ekstrak rumput laut merah, Eucheuma cottonii , timbal asetat, SGOT, SGPT, MDA

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