The effect of Ethanol extract of Redi gedi leaves (Abelmoschus manihot L) on histological rat kidney urolithiasis model

irma santi, Rahmawati ., Lili Tari

Abstract


Urolithiasis or kidney stones is disease symptoms caused by the presence of urinary sediment in the urinary tract. It can be observed histologically by investigating the presence of crystals and tissu damage  such as degeneration hydropis, hemorrhage, necrosis. The aim of  reseach to prove the effect of ethanol extract of red gedi leaves (Abelmoschus manihot L) on histological overview of white rat kidney (Rattus norvegicus) urolithiasis model. This reseach used 15 rat devided into 5 groups. Group 1 was the normal group; group 2 was induced ethylene glycol 0,75% and ammonium chloride 1 %; group 3,4 and 5 were a test group induced ammonium chloride 1 %; group 3,4 and 5 were a test ammonium chloride 0.75 % and 1 % and ethanol extract of red gedi leaves with succesive doses of 10 mg/kgBW, 20 mg/kgBW, 40 mg/kgBW. The data were analyzed statistically using Kruskal wallis test and Mann-Whitney’s advanced test. The result showed that the group of red gedi leaf extract with doses 40 mg/kgBW statically has the best effect as antiurolithiasis on the white rats

Keywords


Urolithiasis, red gedi, Abelmoschus manihot L.

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.