UJI AKTIVITAS ANTIDIARE INFUSA BIJI PEPAYA (Carica papaya) PADA MENCIT JANTAN (Mus musculus) TERINDUKSI Oleum ricini
DOI:
https://doi.org/10.30649/pst.v4i1.64Keywords:
papaya, castor oil, diarrhea indexAbstract
Diarrhea is a major health problem in Indonesia, and West Nusa Tenggara (NTB) is the province with the highest prevalence of diarrheal disease in Indonesia. Papaya (Carica papaya) is empirically used for the management of diarrhea. This study aims to determine the effective empirical dose of infused papaya seeds which were tested in vivo in castor oil-induced mice. This study used 5 treatment groups, namely papaya seeds infusion 1,3 g/kg body weight dan 2,6 g/kg body weight, normal control, negative control, and positive control capsule x containing guava leaf, turmeric rhizome, mojokeling fruit, and pomegranate peel extract. All groups of mice except the normal control group were induced orally with castor oil. LSIR, ALSG, and DI were measured and analyzed using the One Way Anova and post-hoc LSD tests with SPSS v.25 software. Infusion of papaya seeds (Carica papaya) has been shown to have anti-diarrheal efficacy at an empirical dose of 1.3 g/kg body weight in terms of the Average Loose Stool Grade parameter and diarrhea index comparable to capsule X.
Downloads
References
Aas, E. (2003). A Practitioners Perspectives : Traditional Tannin- Treatment Against Intestinal Parasites in Sheep and Cattle. Ethnobotany Research and Applications, (1): 31–37.
Ambari, Y. (2018). Uji aktivitas antidiare ekstrak etanol daun salam (Eugenia polyantha wight) pada mencit putih (Mus musculus) jantan galur balb-c’, Journal of Pharmaceutical Care Anwar Medika. 1(1).
Anas, Y. et al. (2016). Aktivitas antidiare ekstrak etanol daun nangka (artocarpus heterophyllus lam.) dan daun angsana (Pterocarpus indicus wild.) pada mencit jantan galur balb/c. Jurnal Ilmu Farmasi dan Farmasi Klinik, 13:33–41.
Debora, N. et al. (2016). Uji efek antidiare kombinasi ekstrak biji pepaya (Carica papaya l.) dengan daun kesumba keling (Bixa orellana l.) pada mencit (mus musculus). Mulawarman Pharmaceutical Conferences:20–21.
Departemen Kesehatan Republik Indonesia (2000) Parameter Standar Umum Ekstrak Tumbuhan Obat. Edisi Satu. Jakarta: Departemen Kesehatan RI.
Desta, G.T. et al. (2022). Evaluation of Antidiarrheal Activity of 80% Methanol Extract and Solvent Fractions of the Leaves of Withania somnifera (L.) Dunal in Swiss Albino Mice. Hindawi Evidence- based Complementary and Alternative Medicine.
Fokam Tagne, M.A. et al. (2019). Effect of the hydroethanolic extract of bixa orellana linn (Bixaceae) leaves on castor oil- induced diarrhea in swiss albino mice. Hindawi Gastroenterology Research and Practice, 2019.
Gonçalves, F.A. et al. (2008) .Antibacterial activity of guava, Psidium guajava Linnaeus, leaf extracts on diarrhea-causing enteric bacteria isolated from seabob shrimp, Xiphopenaeus kroyeri (Heller). Revista do Instituto de Medicina Tropical de Sao Paulo, 50(1):11-15
Kemenkes RI (2022). Profil Kesehatan Indonesia 2021. Diakses di Pusdatin.Kemenkes.Go.Id
Kumar, B. and Divakar, K. (2008) Evaluation of antidiarrhoeal effect of aqueous and ethanolic extracts of fruit pulp of Terminalia belerica in rats. Acharya Institutes. Available at: https://doi.org/http://13.232.72.61:8080/js pui/handle/123456789/6303.
Lu, J. et al. (2020) ‘Changes of intestinal microflora diversity in diarrhea model of KM mice and effects of Psidium guajava L. as the treatment agent for diarrhea’, Journal of Infection and Public Health, 13(1):16–26.
Mafazah, L. (2013). Ketersediaan Sarana Sanitasi Dasar, Personal Hygiene Ibu dan Kejadian Diare. Jurnal Kesehatan Masyarakat, 8(2):176–182.
Nurwana, Sabilu, Y. and Fachlevy, A.F. (2017). Analisis Faktor Yang Berhubungan Dengan Kejadian Disminorea Pada Remaja Putri Di Sma Negeri 8 Kendari Tahun 2016. Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat Unsyiah, 2(6):85630.
Ojewole, J.A.O., Awe, E.O. and Chiwororo, W.D.H. (2008). Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents. Journal of Smooth Muscle Research, 44(6):195–207.
Salim, A.N., Sumardianto, S, Amalia U. (2018). Efektivitas Serbuk Simplisia Biji Pepaya sebagai Antibakteri pada Udang Putih (Penaeus merguensis) Selama Penyimpanan Dingin. Jurnal Pengolahan Hasil Perikanan Indonesia, 21(2):188.
Sastroamidjojo, S. (2001). Obat Asli Indonesia. 6th edn. Jakarta: Dian Rakyat.
Selviana, S., Trisnawati, E. and Munawarah, S. (2017). Faktor-Faktor Yang Berhubungan Dengan Kejadian Diare Pada Anak Usia 4-6 Tahun. Jurnal Vokasi Kesehatan, 3(1):28.
Sukardi, Mulyarto, A.R. and Safera, W. (2007). Optimasi waktu ekstraksi terhadap kandungan tanin pada bubuk ekstrak daun jambu biji (Psidii folium) serta biaya produksinya. Jurnal Teknologi Pertanian, 8(2): 88–94.
Tripathi, K. (2013) Essentials of Medical Pharmacology. 7th edn. India: Jaypee Brothers Medical Publishers.
Utami, N. and Luthfiana, N. (2016). Faktor-Faktor yang Memengaruhi Kejadian Diare pada Anak. Jurnal Majority, 5:101–106.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
