SKRINING FITOKIMIA DAN UJI POTENSI ANTIKANKER EKSTRAK METANOL KULIT BATANG (Rhizophora mucronata (Lamk.)) MENGGUNAKAN METODE BSLT (Brine Shrimp Lethality Test)
DOI:
https://doi.org/10.30649/pst.v4i2.101Kata Kunci:
Kanker, Rhizophora mucronata, skrining fitokimia, praskrining antikanker, Brine Shrimp lethality TestAbstrak
SKRINING FITOKIMIA DAN UJI POTENSI ANTIKANKER EKSTRAK METANOL KULIT BATANG (Rhizophora mucronata (Lamk)) MENGGUNAKAN METODE BSLT (Brine Shrimp Lethality Test)
Kanker merupakan salah satu penyebab utama kematian di dunia. Terapi utama kanker meliputi pembedahan, kemoterapi, radioterapi. Namun penggunaan obat-obat kemoterapi dapat menimbulkan efek samping seperti rambut rontok, supresi sumsum tulang, resistensi obat. Berdasarkan efek samping tersebut, penelitian ini melakukan penelitian terhadap bahan alam sebagai alternatif untuk pengobatan kanker. Rhizophora mucronata dapat dimanfaatkan sebagai antikanker, yang mana masyarakat dikawasan pesisir atau sekitar hutan mangrove banyak memanfaatkan mangrove sebagai tanaman yang berkhasiat obat, dan dipercaya memiliki efek samping yang minimal sehingga dapat dikembangkan sebagai obat tradisional. Pada penelitian ini dilakukan analisis skrining fitokimia dan uji potensi antikanker ekstrak metanol kulit batang Rhizophora mucronata yang diperoleh dari Pamurbaya, Surabaya, Jawa Timur. Pada penelitian ini menggunakan metode BSLT (Brine Shrimp Lethality Test) untuk uji potensi antikanker dengan nilai LC50 (Letal Concentration) sebagai parameter. Hasil skrining fitokimia ekstrak metanol kulit batang Rhizophora mucronata mengandung tannin, saponin, alkaloid, steroid, flavonoid, antrakinon dan polifenol serta memiliki potensi antikanker dengan nilai LC50 sebesar 120,8656 ppm yang masuk pada kategori toksik.
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