EFEKTIFITAS NEPHROPROTEKTOR EKSTRAK RUMPUT LAUT MERAH (Eucheuma cottonii) PADA MENCIT YANG DIINDUKSI DENGAN LOGAM BERAT TIMBAL
DOI:
https://doi.org/10.30649/pst.v1i1.35Kata Kunci:
Ekstrak rumput laut merah, Eucheuma cottonii , timbal asetat, SGOT, SGPT, MDAAbstrak
Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak rumput laut merah terhadap kadar SGOT dan SGPT serum tikus yang terpapar timbal per oral. Sampel yang digunakan adalah 50 tikus jantan yang dibagi menjadi 5 kelompok: kontrol negatif (tikus diberi CMC / karboksi metil selulosa 0,5%); kontrol positif (tikus diberi CMC 0,5% dan timbal asetat 20 mg / kg BB secara oral satu kali dalam sehari selama 10 hari); dan kelompok perlakuan (tikus diberi ekstrak rumput laut merah 200 mg; 400 mg; 800 mg / kg BB secara oral satu kali sehari selama 28 hari dan timbal asetat 20 mg / kg BB pada hari ke 7, satu jam setelah pemberian ekstrak rumput laut merah selama 21 hari. Pada hari ke 14 diukur kadar MDA, SGOT dan SGPT. Seluruh data dianalisis dengan ANOVA satu arah dan dilanjutkan dengan uji LSD. Hasil menunjukkan bahwa pemberian timbal asetat 20 mg / kg BB per oral selama 21 hari meningkatkan kadar SGOT, SGPT dan MDA secara signifikan. Pemberian ekstrak rumput laut merah dengan dosis 800 mg / kg BB secara signifikan (P <0,05) menurunkan kadar SGPT, SGOT dan MDA dibandingkan dengan kontrol positif. Dari hasil penelitian ini disimpulkan bahwa ekstrak rumput laut merah memiliki aktivitas nephrotoprotektif terhadap timbal asetat yang menginduksi hepatotoksisitas pada tikus.
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