KAJIAN EFEK SAMPING ANTIDEPRESAN TERHADAP FUNGSI SEKSUAL
DOI:
https://doi.org/10.30649/pst.v3i2.49Kata Kunci:
efek samping, efek yang tidak diinginkan, antidepresan, disfungsi seksual,monitorAbstrak
Depresi adalah gangguan kesehatan mental yang merupakan gangguan serius pada suasana hati yang ditandai dengan munculnya gejala penurunan suasana hati (mood), seperti kehilangan suatu minat, energi, konsentrasi dan gangguan pada nafsu makan serta tidur. Salah satu pengobatan mengatasi depresi yaitu dengan menggunakan antidepresan namun disfungsi seksual banyak dilaporkan menjadi salah satu efek samping dari penggunaan antidepresan terutama Selective Serotonin Reuptake Inhibitor (SSRI), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) dan juga terdapat dilaporkan pula antidepresan lain yaitu Antidepressant Tricyclic (TCA). Hasil penelitian ditemukan efek samping penggunaan obat antidepresan yang banyak dilaporkan yaitu penurunan gairah seksual dan gangguan orgasme. Efek samping gangguan fungsional dapat terjadi pada pasien yang mendapat antidepresan golongan SSRI, SNRI dan TCA.
Unduhan
Referensi
A. Kring, S. Johnson, G. Davison, and J. Neale, Abnormal Psychology 12th ed- DSM 5 Update, no. 12th. 2013.
“InfoDatin-Kesehatan-Jiwa”.
B. G. Katzung, Katzung Basic & Clinical Pharmacology 14th Edition. 2018.
M. Sinyor et al., “Antidepressant-placebo differences for specific adverse events in major depressive disorder: A systematic review,” J Affect Disord, vol. 267, 2020, doi: 10.1016/j.jad.2020.02.013.
World Health Organisation, “Depression and other common mental disorders: global health estimates,” World Health Organization, 2017.
S.-M. Wang et al., “Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review,” Chonnam Med J, vol. 54, no. 2, 2018, doi: 10.4068/cmj.2018.54.2.101.
M. Zolnoori et al., “Identifying the Underlying Factors Associated With Patients’ Attitudes Toward Antidepressants: Qualitative and Quantitative Analysis of Patient Drug Reviews,” JMIR Ment Health, vol. 5, no. 4, p. e10726, Sep. 2018, doi: 10.2196/10726.
A. Higgins, M. Nash, and A. M. Lynch, “Antidepressant-associated sexual dysfunction: Impact, effects, and treatment,” Drug, Healthcare and Patient Safety, vol. 2, no. 1. 2010. doi: 10.2147/DHPS.S7634.
E. Jing and K. Straw-Wilson, “Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and potential solutions: A narrative literature review,” Mental Health Clinician, vol. 6, no. 4. 2016. doi: 10.9740/mhc.2016.07.191.
E. O. Laumann, A. Paik, and R. C. Rosen, “Sexual dysfunction in the United States: Prevalence and predictors,” J Am Med Assoc, vol. 281, no. 6, 1999, doi: 10.1001/jama.281.6.537.
A. H. Clayton et al., “Prevalence of sexual dysfunction among newer antidepressants,” Journal of Clinical Psychiatry, vol. 63, no. 4, 2002, doi: 10.4088/JCP.v63n0414.
K. Williams and M. F. Reynolds, “Sexual dysfunction in major depression,” CNS Spectrums, vol. 11, no. SUPPL. 9. 2006. doi: 10.1017/s1092852900026729.
S. T. Lindau and N. Gavrilova, “Sex, health, and years of sexually active life gained due to good health: Evidence from two US population based cross sectional surveys of ageing,” BMJ (Online), vol. 340, no. 7746, 2010, doi: 10.1136/bmj.c810.
P. Sharma, P. Bhardwaj, T. Arif, and R. Singh, “Pharmacology, phytochemistry and safety of aphrodisiac medicinal plants: A review,” In Vitro Free Radical Scavenging and Membrane Stabilizing Activity of Paederia foetida Leaves, vol. 2, 2014.
A. K. Faizah, Y. Andhiarto, and N. Wijayanti, “Uji Aktivitas Minyak Ikan sebagai Antidepresan pada Depresi Kronik secara In Vivo,” Jurnal Sain Med, vol. 10, no. 2. 2018.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2022 JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY
Artikel ini berlisensiCreative Commons Attribution-ShareAlike 4.0 International License.
